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Jatrorrhizine chloride

CAS No. 6681-15-8

Jatrorrhizine chloride ( Neprotine chloride | Yatrorhizine chloride )

产品货号. M21537 CAS No. 6681-15-8

药根碱氯化物是一种有效的、具有口服活性的 uptake-2 转运蛋白抑制剂。它通过抑制 HT22 海马神经元中的 MAPK 通路,在 H2O2 诱导的细胞凋亡中发挥关键的神经保护作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥316 有现货
10MG ¥518 有现货
25MG ¥932 有现货
50MG ¥1442 有现货
100MG ¥2171 有现货
500MG ¥4479 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Jatrorrhizine chloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    药根碱氯化物是一种有效的、具有口服活性的 uptake-2 转运蛋白抑制剂。它通过抑制 HT22 海马神经元中的 MAPK 通路,在 H2O2 诱导的细胞凋亡中发挥关键的神经保护作用。
  • 产品描述
    Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
  • 体外实验
    Jatrorrhizine has antiplasmodial and antiamoebic activity, it against Plasmodium falciparum and E. histolytica with IC50 values of 3.15 and 82.7 μM, respectively.The hOCT2 (organic cation transporter 2), hOCT3, and PMAT (plasma membrane monoamine transporter) are capable of transporting monoamine neurotransmitters in the brain.Jatrorrhizine has the inhibitory potency of jatrorrhizine on 5-HT and NE uptake in hOCT2-, hOCT3-, and PMAT-transfected cells. Jatrorrhizine strongly inhibits PMAT-mediated MPP+ uptake with an IC50 value of 1.05 μM and reduces 5-HT and NE uptake mediated by hOCT2, hOCT3, and hPMAT with IC50 values of 0.1-1 μM (for OCT2 and OCT3) and 1-10 μM (for PMAT).Clearance of neurotransmitters released into the synaptic cleft is defined by two distinct processes. Uptake-1, the common target of current applied antidepressants, is comprised of the serotonin transporter (SERT),the “SERT”, had a high affinity but low capacity to take up [3H]5-HT. Uptake-2 transporters are an important supplementary regulation system in monoamine clearancethought to be the “NET”, has low affinity but high capacity to take up [3H]5-HT into brain slices.Jatrorrhizine significantly inhibited 5-HT and NE uptake in synaptosomes at 25 μM and 50 μM.
  • 体内实验
    Jatrorrhizine chloride (intraperitoneal?injection; 5, 10, 20 mg/kg) can significantly reduce the duration of immobility when compared with vehicle control group in tail suspension test (TST). Animal Model:Male ICR albino mice Dosage:5, 10, 20 mg/kg Administration:Intraperitoneal?injection; 5, 10, 20 mg/kg Result:Reduced immobility period in tail suspension test.
  • 同义词
    Neprotine chloride | Yatrorhizine chloride
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    OCT| PMAT
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    6681-15-8
  • 分子量
    373.8
  • 分子式
    C20H20ClNO4
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:5 mg/mL (13.38 mM)
  • SMILES
    COc(ccc1cc(-c(cc2OC)c(CC3)cc2O)[n+]3cc11)c1OC.[Cl-]
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Sun S et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.
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